By Paul Ebeling on July 19, 2017 

 

Cannabidiol(CBD) has come into the medical cannabis scene like no other natural compound has ever done.

Cannabidiol(CBD) has come into the medical cannabis scene like no other natural compound has ever done.

 

Hemp CBD Vs Cannabis CBD, the Difference

$POTN

CBD stands for phytocannabinoid Cannabidiol. It has come into the medical cannabis scene like no other natural compound has ever done.

CBD has received lots of media attention over the past few years; however, there are many people that have questions about it:

Below is everything one need know about CBD and some, as follows:

  1. Cannabidiol was discovered in Y 1940 from the hemp plant by chemist Roger Adams at the University of Illinois. In Y 1963, Israeli scientists elucidated its exact chemical structure. Subsequent research in the 1970’s showed that CBD did not cause intoxication like THC, and was thought to be an inactive cannabinoid. Scientific interest in CBD was of little interest until the early 1990’s, when the important discovery of the endocannabinoid system renewed interest in numerous phytocannabinoids. Over the past 10 years, hundreds of scientific articles researching how CBD interacts with the human brain and body have been published, and the results are eye-opening, to say the least.
  2. CBDA, cannabidiolic acid, is the 2nd most common phytocannabinoid produced in the cannabis drug-variety plant, the most common being THC, and the most common phytocannabinoid in the fiber variety plant, Hemp. CBDA, found in the raw cannabis flower, is converted to CBD when heated. CBD-rich plants were quite rare in the United States until around Y 2009, when reports of CBD’s therapeutic value started to appear in the media. Cannabis growers began testing their plants for CBD and made efforts to stabilize CBD-rich varieties. Now have a number of CBD-rich chemovars; they include: Charlotte’s Web, AC/DC, Cannatonic, Harlequin, Sour Tsunami, Blue Jay Way, and lots of others.
  3. CBD Absorption & Metabolism: The bioavailability of CBD after inhalation is about 31%. CBD is absorbed poorly and erratically when ingested. Sublingual absorption rates are low, but less variable than oral ingestion. CBD is metabolized in the liver, where it is converted to 7-hydroxy-CBD by enzymes in the P450 system. Most of this breakdown product is excreted in feces, with a small amount excreted in urine.
  4. CBD Mechanism of Action: CBD does not bind to the cannabinoid receptor the same way that THC does, which is why it is not intoxicating. CBD modulates the way that THC binds to the cannabinoid receptor and blocks the conversion of THC to the more psychoactive 11-hydroxy-THC. CBD also inhibits the reuptake of the endocannabinoid anandamide, thus enhancing the endocannabinoid system. CBD works at numerous non-cannabinoid receptors, such as the 5-HT1A (hydroxytryptamine) serotonin receptor, giving an antidepressant effect, the TRPV1 (vanilloid) receptor, giving analgesic and anti-inflammatory effects, and the peroxisome proliferator activated receptors (PPARs), with multiple effects, such as anti-proliferation of certain cancer cells, neuroprotection, and cardioprotection. CBD changes the way that GABA, an inhibitory neurotransmitter, binds to the GABA receptor, enhancing the calming, anti-anxiety effects of GABA. CBD has been shown to reduce drug-seeking behavior and can have therapeutic effects on THC withdrawal and nicotine dependence.

Medicinal Properties of CBD

CBD has multiple targets of action, which means that it works at many different places, giving it numerous medicinal properties, which include:

  1. Potent anti-inflammatory
  2. Antioxidant
  3. Neuroprotectant
  4. Anticonvulsant
  5. Analgesic (pain reliever)
  6. Anxiolytic (anti-anxiety)
  7. Antidepressant
  8. Antipsychotic
  9. Antispasmodic
  10. Anti-cancer agent

CBD modulates the intoxicating effects of THC and reduces the adverse effects that some people experience with THC, rapid heartbeat, anxiety, and short-term memory loss.

At the same time, when CBD is taken with THC to treat pain, the combination reduced pain more significantly than THC alone.

In low doses, CBD is described as alerting, in high doses (300 mg) it can be sedating. And CBD has little side effects, even at high doses.

Hemp CBD vs. Marijuana CBD

CBD is produced in both Hemp/fiber variety and drug variety cannabis plants.

The Big Q: Are they the same compound?

The Big A: Yes, and numerous studies have revealed that cannabinoids such as CBD work best when other cannabinoids and terpenoids are present; a synergy termed “the entourage effect.

Hemp is virtually devoid of other cannabinoids and terpenoids.

And Industrial Hemp contains very little CBD, necessitating a large number of Hemp plants to obtain what can be obtained from just one CBD-rich drug variety of the plant.

An excellent study from Israel in Y 2015 showed the scientific community that whole-plant CBD, containing cannabinoids and terpenoids, was superior to single molecule CBD, with whole plant extract having a wider therapeutic window and better efficacy at lower doses.

The Big Q2: What should a patient/user of Hemp based CBD look out for?

Most people know that there are a small number of Hemp products on the market that are labeled Hemp to comply with governmental regulations that require these products to have less than 0.3% THC, but they are robust, with cannabinoids and terpenoids.

Other products are devoid of all cannabinoids, including CBD, despite the manufacturers’ claims.

In Y’s 2015 and 2016, the US FDA purchased a number of CBD products online and tested them for the presence of CBD and other cannabinoids, finding that the amount of CBD claimed on the labels was mostly inaccurate; some products did not contain any CBD.

In the US states that have medical cannabis laws, it is best to obtain products from licensed suppliers who share their test results, which should validate the product’s robust cannabinoid and terpenoid profiles.

If obtaining Hemp through online outlets, thorough research is required as there are many false claims being made.

Fact: CBD is an amazing compound. There are very few medicines that have such a long list of beneficial properties with little to no side effect, and are completely natural.

Many patients using CBD as medicine experience life-changing relief of symptoms, and are able to discontinue ineffective and toxic medications.

Notably, CBD is classified as a Schedule I federally illegal substance that is still prohibited from being thoroughly researched. Medical science must be freed to study Hemp’s medicinal benefits to fully understand its impact on human health.

Recently, I learned that there is a leader in Cannabidiol (CBD) innovation in the US; Diamond CBD Inc., a wholly owned subsidiary of PotNetwork Holdings Inc. (OTCMKT: POTN), the firm has developed cannabis and Hemp-derived therapeutic grade nutraceuticals and medical cannabis products with a broad range of applications for human health.

These innovative CBD fully plant-based nutraceutical products are non-psychoactive, as they contain just trace amounts of THC.

And they are legal in all 50 US states.

Focusing on unique and innovative product delivery systems PotNetwork Holdings Inc. (OTCMKT: POTN) is developing therapeutic products and nutraceuticals manufactured according to the highest standards, and maintaining the highest levels of compliance across the supply chain.

The firm’s distinguished Israeli scientists have standardized dosages designed and adapted for several medical conditions, including pain, anxiety disorders, metabolic disorders and inflammatory disorders.

Monday, POTN announced its Q-2 results and future expectations, which are as follows:

The firm’s June 2017 revenues marked a record $1.1-M, and that Q-2 revenue rose to $3.2-M, significantly exceeding the Company’s Q-1 of  Y 2017 results of $1.9-M, totaling $5.1-M for 1-H of y 2017

 

Revenue expectation for 2-H of Y 2017 is  $1.1-M/month or $6.6-M for annual Y 2017 revenue of $8.4-M.

The company is beating its numbers on the revenue side.

Chief Executive Gary Blum said, “Management believes that this will continue to build momentum into the summer, with heightened expectation for Diamond CBD’s Hemp-derived consumable product line. Our objective is to continue driving POTN’s shareholder value”

Bruce Barrens, POTN’s Brand Ambassador noted, “POTN manufactures safe, CBD-rich, therapeutic products that are unique in composition, standardized in formulation and dose, and administered by proprietary delivery technologies, enhancing bio-availability and absorption. Diamond CBD delivers products to the highest standard for efficacy, safety, quality, and consistency.”